A preparation method of tosylhydrazide with high purity was established, by the
reaction of MeC6H4SO2Cl (I) with H2NNH2·H2O(II)
in presence of benzene as solvent and mole ratio of I-II 1:2 at 60-70°C for
1.5h, with the yield of80.6% product was obtained.
It is a white crystalline
solid after being purified, mp 105°C(decomposition).
The effective process for the production of 1,2,3-triazole is summarized as
follows: A solution of tosylhydrazide and acetic acid in methanol was added
drop-wise into a stirred solution of glyoxal in methanol followed by bubbling a
stream of ammonia. The reaction mixture was stirred for 15h at room
temperature, the product was isolated by the residue distillation. When the
mole ratio of tosylhydrazide and glyoxal is 1:2.7, it gives the yield of 66.8%
for 1H-1,2,3-triazole. The pure product is a pale yellow liquid, mp.23-25°C.
The total yield of 1,2,3-triazole is up to 53.8% in the procedure from MeC6H4SO2Cl
as one material. So the procedure is advisable for its economy benefit
Tazobactam is a
compound that inhibits the action of bacterial β-lactamases. It is combined with the extended spectrum
β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam (trade name Tazocin; also Zosyn, Piprataz). It is one of the preferred antibiotic treatments
for community-acquired
pneumonia (CAP)
caused by Pseudomonas aeruginosa. It broadens the spectrum of piperacillin by making
it effective against organisms that express β-lactamase and would normally
degrade piperacillin. Tazobactam sodium is a derivative of the penicillin
nucleus and is a penicillanic
acid sulfone
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